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Studying Emergent Behaviours in Morphogenesis Using Signal Spatio-Temporal Logic

Bartocci, Ezio
•
BORTOLUSSI, LUCA
•
Milios, Dimitrios
altro
Sanguinetti, Guido
2015
  • conference object

Abstract
Pattern formation is an important spatio-temporal emergent behaviour in biology. Mathematical models of pattern formation in the stochastic setting are extremely challenging to execute and analyse. Here we propose a formal analysis of the emergent behaviour of stochastic reaction diffusion systems in terms of Signal Spatio-Temporal Logic, a recently proposed logic for reasoning on spatio-temporal systems. We present a formal analysis of the spatio-temporal dynamics of the Bicoid morphogen in Drosophila melanogaster, one of the most important proteins in the formation of the horizontal segmentation in the development of the fly embryo. We use a recently proposed framework for statistical model checking of stochastic systems with uncertainty on parameters to characterise the parametric dependence and robustness of the French Flag pattern, highlighting non-trivial correlations between the parameter values and the emergence of the patterning.
DOI
10.1007/978-3-319-26916-0_9
Archivio
http://hdl.handle.net/11368/2860803
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84955306297
http://link.springer.com/chapter/10.1007/978-3-319-26916-0_9
Diritti
open access
license:digital rights management non definito
license:digital rights management non definito
FVG url
https://arts.units.it/request-item?handle=11368/2860803
Soggetti
  • Pattern Formation

  • Spatio-temporal logic...

  • system design

  • model checking

  • parameter estimation

Scopus© citazioni
13
Data di acquisizione
Jun 7, 2022
Vedi dettagli
Visualizzazioni
2
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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