Synthesis and Molecular Modeling Studies of Fullerene-Trimethoxyindole-Oligonucleotide Conjugates as Possible Probes for Studying Photochemical Reactions in DNA Triple Helices
The synthesis of novel functionalized fullerene derivatives
containing DNA minor groove binders is reported. In order
to construct sequence-specific probes for DNA photomodification,
the compounds were attached to a triple helix forming
oligonucleotide, and the formation of triplexes was monitored. The triplex formation was demonstrated, but the
presence of fullerene moieties gives rise to a high degree of
instability. Molecular modeling studies on these supramolecular
structures provided useful information for the current
study and for future developments.
