While Galileo studied simple linear systems, modern science attempts to study complex, multi-parameter systems, where the rigid Galilean method just cannot work. The problem is that, while it is obvious that we can measure only what we can measure, that’s not necessarily what we want, or need, to measure. Tests based on “surrogate endpoints” may well be the best we can do in medicine and other fields, but we should understand that the results are not, and cannot be, a source of absolute scientific truth. We need a new scientific method to work on these systems.