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X-Ray Phase Contrast Tomography Reveals Early Vascular Alterations and Neuronal Loss in a Multiple Sclerosis Model

Cedola, A.
•
Bravin, A.
•
Bukreeva, I.
altro
Uccelli, A.
2017
  • journal article

Periodico
SCIENTIFIC REPORTS
Abstract
The degenerative effects of multiple sclerosis at the level of the vascular and neuronal networks in the central nervous system are currently the object of intensive investigation. Preclinical studies have demonstrated the efficacy of mesenchymal stem cell (MSC) therapy in experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis, but the neuropathology of specific lesions in EAE and the effects of MSC treatment are under debate. Because conventional imaging techniques entail protocols that alter the tissues, limiting the reliability of the results, we have used non-invasive X-ray phase-contrast tomography to obtain an unprecedented direct 3D characterization of EAE lesions at micro-to-nano scales, with simultaneous imaging of the vascular and neuronal networks. We reveal EAE-mediated alterations down to the capillary network. Our findings shed light on how the disease and MSC treatment affect the tissues, and promote X-ray phase-contrast tomography as a powerful tool for studying neurovascular diseases and monitoring advanced therapies.
DOI
10.1038/s41598-017-06251-7
WOS
WOS:000405895000042
Archivio
http://hdl.handle.net/11368/2919805
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85025155124
https://www.nature.com/articles/s41598-017-06251-7.pdf
Diritti
open access
FVG url
https://arts.units.it/bitstream/11368/2919805/1/2017_CedolaEtAl_ScientificReports.pdf
Soggetti
  • Multidisciplinary

Scopus© citazioni
47
Data di acquisizione
Jun 14, 2022
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Web of Science© citazioni
57
Data di acquisizione
Mar 24, 2024
Visualizzazioni
1
Data di acquisizione
Apr 19, 2024
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