The Neo-Deterministic Seismic Hazard Assessment (NDSHA), based on the generation of synthetic seismograms from a set of earthquake sources and layered anelastic structural models, has been applied at regional scale in the Iberian Peninsula. Two seismogenic source models are combined: one of polygonal zones and a second one using nodes obtained by morphostructural analysis and pattern recognition techniques. Hazard maps of maximum ground displacement, Dmax, maximum ground velocity, Vmax, and design ground acceleration, DGA, are produced with a maximum frequency content of 1 Hz. NDSHA results show largest Dmax values (class 7-15 cm) in central-western Portugal and similar high Vmax (class 8-15 cm/s) both in the west and in the east of the Iberian Peninsula. DGA reaches its highest values (class 0.15-0.30 g) in central-western Portugal, and (class 0.08-0.15 g) in eastern Spain.