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Chronic α-synuclein accumulation in rat hippocampus induces lewy bodies formation and specific cognitive impairments

Kasongo, D. W.
•
de Leo, G.
•
Vicario, N.
altro
Legname, G.
2020
  • journal article

Periodico
ENEURO
Abstract
Occurrence of Lewy bodies (LBs)/Lewy neurites (LNs) containing misfolded fibrillar a-synuclein (a-syn) is one of the pathologic hallmarks of memory impairment-linked synucleinopathies, such as Parkinson’s disease (PD) and dementia with LBs (DLB). While it has been shown that brainstem LBs may contribute to motor symptoms, the neuropatho-logical substrates for cognitive symptoms are still elusive. Here, recombinant mouse a-syn fibrils were bilaterally injected in the hippocampus of female Sprague Dawley rats, which underwent behavioral testing for sensorimotor and spatial learning and memory abilities. No sensorimotor deficits affecting Morris water maze task performance were observed, nor was any reference memory disturbances detectable in injected animals. By contrast, significant impairments in working memory performance became evident at 12 months postinjection. These deficits were associated to a time-dependent increase in the levels of phosphorylated a-syn at Ser129 and in the stereologically esti-mated numbers of proteinase K (PK)-resistant a-syn aggregates within the hippocampus. Interestingly, pathologic a-syn aggregates were found in the entorhinal cortex and, by 12 months postinjection, also in the vertical limb of the diagonal band and the piriform cortices. No pathologic a-syn deposits were found within the substantia nigra (SN), the ventral tegmental area (VTA), or the striatum, nor was any loss of dopaminergic, noradrenergic, or cholinergic neurons detected in a-syn-injected animals, compared with controls. This would suggest that the behavioral impairmentsseeninthea-syn-injected animals might be determined by the long-term a-syn neuropathology, rather than by neurodegeneration per se, thus leading to the onset of working memory deficits.
DOI
10.1523/ENEURO.0009-20.2020
WOS
WOS:000571515500009
Archivio
http://hdl.handle.net/20.500.11767/117541
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85086524143
Diritti
open access
Soggetti
  • Hippocampus

  • Preformed fibrils

  • Rat

  • Spatial working memor...

  • Synucleinopathy

  • α-synuclein

  • Settore BIO/10 - Bioc...

Scopus© citazioni
1
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
8
Data di acquisizione
Mar 23, 2024
Visualizzazioni
3
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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