Seborrheic dermatitis is a very common chronic dermatitis occurring in the areas of the skin rich in sebaceous glands. The etiopathogenetic causes are not definitively known, the refore treatment is only symptomatic and not resolutive. The objective of the present study was to investigate the efficacy and the tolerance of a cream containing furalglucitole, 18-beta- glycyrrhetic acid and allantoin in the treatment of seborrheic dermatitis of the face. Sixty patients HIV-negative, 41 males and 29 females, between 15 and 68 years old, with seborrheic dermatitis of the face were included in the study. The cream was used once a day for three months. Nine patients dropped out. Two patients had a slight improvement, while 49 subjects had a prompt remission of the dermatitis. The cream was well tolerated and no side effects were observed. These results suggest that this cream may be an alternative treatment of seborrheic dermatitis of the face.