We estimate the effect of weather conditions on wine quality (measured by tasting ratings) using panel data from a geographically homogeneous region in terms of soil and climate, but where both reds and whites are produced. We find that whites react to the weather very differently from reds; in particular, we identify a tradeoff between spring and summer temperatures. Moreover, substantial differences emerge even among individual grape varieties. The results allow for an assessment of the challenges faced by the wine industry in the context of global warming and suggest adaptation strategies based on substitution between grape varieties.