In Italy today spatial accessibility still remains a significant challenge for spatial regeneration in small, medium, and large cities. Despite the existence of national laws promoting the implementation of Plans for the Removal of Architectural Barriers (PEBAs; Laws no. 41/1986, 104/1992), over time their application has been limited. Attention to these issues has been growing only recently, and local efforts have been made in public works and urban planning. Thanks to the Regional Law no. 10/2018 and the launch of the project FVG Accessibile, the Autonomous Region Friuli Venezia Giulia (RA FVG) stands out among the most virtuous Italian administrations. The institutional partnership working on the project includes the Universities of Trieste (UNITS) and Udine (UNIUD); the aim is to develop operational tools addressed both to improve spatial accessibility at the regional and local scales, and increase the quality of urban and architectural design.