Logo del repository
  1. Home
 
Opzioni

Salt blocks the renal benefits of ramipril in diabetic hypertensive rats

FABRIS, BRUNO
•
Jackson, B
•
Johnston, Ci
1991
  • journal article

Periodico
HYPERTENSION
Abstract
To establish if the benefit of angiotensin converting enzyme inhibitor therapy in retarding progressive diabetic renal injury is due to a specific intrarenal effect of the systemic hypotensive effect, we studied the effect of long-term ramipril treatment on blood pressure, glomerular filtration rate, and urinary protein excretion in streptozotocin-diabetic spontaneously hypertensive rats. The hypotensive effect of ramipril was prevented by a high salt diet, which did not alter the degree of renal angiotensin converting enzyme inhibition. Three weeks after uninephrectomy and induction of diabetes, rats were allocated to three groups. Groups 1 and 2 were given 1% NaCl, whereas group 3 was given water as drinking solution. One week later, groups 2 and 3 received 0.4 mg/kg/day ramipril in their drinking solution, which was continued over a 2-month period. Ramipril produced a blood pressure fall only in water-drinking rats (group 3) despite a similar reduction in plasma and renal angiotensin converting enzyme activity in groups 2 and 3. Salt-loaded rats had a progressive increase in urinary protein excretion over the duration of study. Ramipril treatment prevented an increase in protein excretion only in animals given water and with a reduced systolic blood pressure. Glomerular filtration rate was similar in all three groups. Ramipril treatment improved animal survival independently of a reduction in blood pressure or an effect on proteinuria. Although it is possible that angiotensin converting enzyme inhibitors have specific intrarenal effects reducing progression of diabetic proteinuria, concomitant control of systemic blood pressure appears to be necessary to demonstrate a benefit.
DOI
10.1161/01.HYP.17.4.497
WOS
WOS:A1991FG24600005
SCOPUS
2-s2.0-0025729399
Archivio
http://hdl.handle.net/11368/1693686
http://hyper.ahajournals.org/content/17/4/497.short?cited-by=yes&legid=hypertensionaha;17/4/497
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/1693686
Soggetti
  • renal hypertension

  • diabetes

  • salt

  • angiotensin convertin...

  • albuminuria

  • spontaneously hyperte...

Web of Science© citazioni
43
Data di acquisizione
Jun 15, 2022
google-scholar
Get Involved!
  • Source Code
  • Documentation
  • Slack Channel
Make it your own

DSpace-CRIS can be extensively configured to meet your needs. Decide which information need to be collected and available with fine-grained security. Start updating the theme to match your nstitution's web identity.

Need professional help?

The original creators of DSpace-CRIS at 4Science can take your project to the next level, get in touch!

Realizzato con Software DSpace-CRIS - Estensione mantenuta e ottimizzata da 4Science

  • Impostazioni dei cookie
  • Informativa sulla privacy
  • Accordo con l'utente finale
  • Invia il tuo Feedback