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Characterizing Metastatic HER2-Positive Gastric Cancer at the CDH1 Haplotype

Caggiari, Laura
•
Miolo, Gianmaria
•
Buonadonna, Angela
altro
De Re, Valli
2017
  • journal article

Periodico
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Abstract
The CDH1 gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal growth factor receptor 2 (HER2) is amplified and overexpressed in a portion of GC. HER2 is an established therapeutic target in metastatic GC (mGC). Trastuzumab, in combination with various chemotherapeutic agents, is a standard treatment for these tumors leading to outcome improvement. Unfortunately, the survival benefit is limited to a fraction of patients. The aim of this study was to improve knowledge of the HER2 and the E-cadherin alterations in the context of GC to characterize subtypes of patients that could better benefit from targeted therapy. An association between the P7-CDH1 haplotype, including two polymorphisms (rs16260A-rs1801552T) and a subset of HER2-positive mGC with better prognosis was observed. Results indicated the potential evaluation of CDH1 haplotypes in mGC to stratify patients that will benefit from trastuzumab-based treatments. Moreover, data may have implications to understanding the HER2 and the E-cadherin interactions in vivo and in response to treatments.
DOI
10.3390/ijms19010047
WOS
WOS:000424407200045
SCOPUS
2-s2.0-85039065455
Archivio
http://hdl.handle.net/11368/2968125
https://www.mdpi.com/1422-0067/19/1/47
Diritti
open access
FVG url
https://arts.units.it/bitstream/11368/2968125/1/208333_OA.pdf
Soggetti
  • E-cadherin

  • CDH1

  • HER2

  • metastatic gastric ca...

  • rs16260

  • rs1801552

Scopus© citazioni
10
Data di acquisizione
Jun 15, 2022
Vedi dettagli
Web of Science© citazioni
13
Data di acquisizione
Jun 17, 2022
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