Logo del repository
  1. Home
 
Opzioni

Folding and fibrillogenesis: clues from beta2-microglobulin

RENNELLA, E
•
CORAZZA, A
•
GIORGETTI, S
altro
ESPOSITO, G
2010
  • journal article

Periodico
JOURNAL OF MOLECULAR BIOLOGY
Abstract
Renal failure impairs the clearance of β2-microglobulin from the serum, with the result that this protein accumulates in joints under the form of amyloid fibrils. While the molecular mechanism leading to deposition of amyloid in vivo is not totally understood, some organic compounds, such as trifluoroethanol (TFE), are commonly used to promote the elongation of amyloid fibrils in vitro. This article gives some insights into the structural properties and the conformational states of β2-microglobulin in the presence of TFE, using both the wild-type protein and the mutant Trp60Gly. The structure of the native state of the protein is rather insensitive to the presence of the alcohol, but the stability of this state is lowered in comparison to some other conformational states. In particular, a native-like folding intermediate is observed in the presence of moderate concentrations of TFE. Instead, at higher concentrations of the alcohol, the population of a disordered native-unlike state is dominant and correlates with the ability to elongate fibrils.
DOI
10.1016/j.jmb.2010.06.016
WOS
WOS:000281019600011
SCOPUS
2-s2.0-77955086949
Archivio
http://hdl.handle.net/11390/878423
Diritti
closed access
Scopus© citazioni
32
Data di acquisizione
Jun 2, 2022
Vedi dettagli
Web of Science© citazioni
30
Data di acquisizione
Jun 7, 2022
google-scholar
Get Involved!
  • Source Code
  • Documentation
  • Slack Channel
Make it your own

DSpace-CRIS can be extensively configured to meet your needs. Decide which information need to be collected and available with fine-grained security. Start updating the theme to match your nstitution's web identity.

Need professional help?

The original creators of DSpace-CRIS at 4Science can take your project to the next level, get in touch!

Realizzato con Software DSpace-CRIS - Estensione mantenuta e ottimizzata da 4Science

  • Impostazioni dei cookie
  • Informativa sulla privacy
  • Accordo con l'utente finale
  • Invia il tuo Feedback