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Combined Orofacial Aspergillosis and Mucormycosis: Fatal Complication of a Recurrent Paediatric Glioma—Case Report and Review of Literature

CHERMETZ, MADDALENA
•
GOBBO, MARGHERITA
•
RUPEL, KATIA
altro
BIASOTTO, MATTEO
2016
  • journal article

Periodico
MYCOPATHOLOGIA
Abstract
Mucormycosis and aspergillosis are two opportunistic fungal infections, which can evolve into life-threatening complications. They generally affect patients with relevant risk factors such as immunocompromisation or long-term use of antibiotics or corticosteroids. Treatment usually combines medical and surgical approaches, often including extended necrosectomies, although the prognosis of generalized fungal infections is very poor. In this paper, we present the case of a 17-year-old girl affected by combined aspergillosis and mucormycosis, following treatment of a recurrent glioma. The patient was hospitalized for a suspected cellulitis of the right hemi-face, involving frontal maxillary area and the upper airways and was immediately put on intravenous antibiotic therapies; after performing nasal septum and maxillary biopsies, concomitant mucormycosis and aspergillosis were diagnosed and antimycotic therapy with liposomal B-amphotericin was administered. After evaluation by the oral surgeon and otolaryngologist, surgical cranio-facial necrosectomy was suggested, but refused by the parents of the patient. The girl died only few days later, due to a respiratory arrest. Awareness of this pathology with prompt diagnosis and early treatment may improve the outcome of these infections and reduce the mortality.
DOI
10.1007/s11046-016-0021-8
WOS
WOS:000382938400013
Archivio
http://hdl.handle.net/11368/2878112
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84976260788
http://link.springer.com/article/10.1007/s11046-016-0021-8
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2878112
Soggetti
  • Aspergillosi

  • Early diagnosi

  • Invasive fungal infec...

  • Mucormycosi

  • Plant Science

  • Agronomy and Crop Sci...

  • Applied Microbiology ...

  • Microbiology

  • Veterinary (miscellan...

Scopus© citazioni
18
Data di acquisizione
Jun 14, 2022
Vedi dettagli
Web of Science© citazioni
18
Data di acquisizione
Mar 22, 2024
Visualizzazioni
4
Data di acquisizione
Apr 19, 2024
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