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Interfacing neurons with carbon nanotubes:(re)engineering neuronal signaling

FABBRO, ALESSANDRA
•
CELLOT, GIADA
•
PRATO, MAURIZIO
•
BALLERINI, Laura
2011
  • journal article

Journal
PROGRESS IN BRAIN RESEARCH
Abstract
Abstract: Carbon nanotubes (CNTs) are cylindrically shaped nanostructures made by sheets of graphene rolled up to form hollow tubes. Owing to their unique range of thermal, electronic, and structural properties, CNTs have been rapidly developing as a technology platform for biological and medical applications, including those designed to develop novel neuro-implantable devices. Depending on their structure, CNTs combine an incredible strength with an extreme flexibility. Further, these materials exhibit physical and chemical properties which allow them to efficiently conduit electrical current in electrochemical interfaces. CNTs can be organized in scaffolds made up of small fibers or tubes with diameters similar to those of neural processes such as axons and dendrites. Recently, CNT scaffolds have been found to promote growth, differentiation, and survival of neurons and to modify their electrophysiological properties. These features make CNTs an attractive material for the design of nano–bio hybrid systems able to govern cell-specific behaviors in cultured neuronal networks. The leading scope of this short review is to highlight how nanotube scaffolds can impact on neuronal signaling ability. In particular, we will focus on the direct and specific interactions between this synthetic nanomaterial and biological cell membranes, and on the ability of CNTs to improve interfaces developed to record or to stimulate neuronal activity. CNTs hold the potential for the development of innovative nanomaterial-based neurological implants. Therefore, it is particularly relevant to improve our knowledge on the impact on neuronal performance of interfacing nerve cells with CNTs.
DOI
10.1016/B978-0-444-53815-4.00003-0
WOS
WOS:000311038900019
SCOPUS
2-s2.0-80051885786
SourceArchive
http://hdl.handle.net/11368/2356337
Rights
metadata only access
Subjects
  • Keywords: carbon nano...

  • neuronal network

  • spontaneous activity

  • hippocampal culture

  • afterdepolarization

  • neural interfaces

Web of Science© citazioni
22
Data di acquisizione
Jun 2, 2022
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