Logo del repository
  1. Home
 
Opzioni

Stereoselective synthesis of non symetric dihydroxyethylene dipeptide isosteres via epoxyalcohols derived from α-amino acids

BENEDETTI, FABIO
•
M. MAGNAN
•
NORBEDO, STEFANO
altro
TOSSI, ALESSANDRO
1999
  • journal article

Periodico
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Abstract
C2 symmetric and non-symmetric pseudopeptide inhibitors of HIV-1 protease, containing a S,S,S,S-diaminodiol isostere have been obtained by a synthetic strategy designed to couple a high degree of stereochemical control with complete flexibility in the choice of residues in the central core and flanking chains. Using this approach, inhibitors with IC50 values in the low nanomolar range were assembled from readily available aminoacids and carboxylic acids, chosen with the aid of molecular modelling.
DOI
10.1016/S0960-894X(99)00529-6
WOS
WOS:000083244000025
Archivio
http://hdl.handle.net/11368/1708332
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0033581602
Diritti
metadata only access
Soggetti
  • HIV

  • pseudopeptide

  • peptidomimetic

  • aspartic protease inh...

Web of Science© citazioni
14
Data di acquisizione
Mar 25, 2024
google-scholar
Get Involved!
  • Source Code
  • Documentation
  • Slack Channel
Make it your own

DSpace-CRIS can be extensively configured to meet your needs. Decide which information need to be collected and available with fine-grained security. Start updating the theme to match your nstitution's web identity.

Need professional help?

The original creators of DSpace-CRIS at 4Science can take your project to the next level, get in touch!

Realizzato con Software DSpace-CRIS - Estensione mantenuta e ottimizzata da 4Science

  • Impostazioni dei cookie
  • Informativa sulla privacy
  • Accordo con l'utente finale
  • Invia il tuo Feedback