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Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review

Lallas, Aimilios
•
Kyrgidis, Athanassios
•
Ferrara, Gerardo
altro
Argenziano, Giuseppe
2014
  • journal article

Periodico
THE LANCET ONCOLOGY
Abstract
Sentinel lymph node biopsy has been proposed as a diagnostic method for estimation of the malignant potential of atypical Spitz tumours. However, although cell deposits are commonly detected in the sentinel lymph nodes of patients with atypical Spitz tumours, their prognosis is substantially better than that of patients with melanoma and positive sentinel lymph node biopsies. We did a systematic review of published reports to assess the role of sentinel lymph node biopsy as a prognostic method in the management of atypical Spitz tumours. The results of our analysis did not show any prognostic benefit of sentinel lymph node biopsy; having a positive sentinel lymph node does not seem to predict a poorer outcome for patients with atypical Spitz tumours. These findings indicate that, especially in the paediatric population, it might be prudent initially to use complete excision with clear margins and careful clinical follow-up in patients with atypical Spitz tumours.
DOI
10.1016/S1470-2045(13)70608-9
WOS
WOS:000334301900020
Archivio
http://hdl.handle.net/11368/2923305
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84897087251
Diritti
metadata only access
Soggetti
  • Human

  • Lymph Node

  • Lymphatic Metastasi

  • Nevus, Epithelioid an...

  • Patient Selection

  • Predictive Value of T...

  • Prognosi

  • Risk Factor

  • Skin Neoplasm

  • Sentinel Lymph Node B...

Scopus© citazioni
99
Data di acquisizione
Jun 7, 2022
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Web of Science© citazioni
99
Data di acquisizione
Mar 28, 2024
Visualizzazioni
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Data di acquisizione
Apr 19, 2024
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