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Circulating PV-1 as a marker of celiac disease-associated liver injury

Luigina De Leo
•
Samuele Naviglio
•
Serena Vatta
altro
Tarcisio Not
2020
  • journal article

Periodico
BIOMARKERS IN MEDICINE
Abstract
Aim: To investigate the role of endothelial PV-1 in patients with untreated celiac disease (CD)-associated liver injury. Materials & methods: PV-1 and PV-1 mRNA were measured in intestinal biopsies from untreated CD patients with elevated or normal alanine transaminase levels, controls, patients with inflammatory bowel disease and patients with toxic liver injury. Circulating PV-1 levels were also evaluated. Results: Circulating PV-1 levels were significantly increased in the serum of patients with CD-associated liver injury and reverted to normal following a gluten-free diet. Mucosal PV-1 and PV-1 mRNA were no different in patients with CD-associated liver injury. Conclusion: Serum but not mucosal PV-1 represents a marker of gluten-dependent liver injury and response to a gluten-free diet in patients with untreated CD.
DOI
10.2217/bmm-2020-0281
WOS
WOS:000600600200001
SCOPUS
2-s2.0-85098231504
Archivio
http://hdl.handle.net/11368/2990437
https://www.futuremedicine.com/doi/10.2217/bmm-2020-0281
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2990437
Soggetti
  • celiac disease

  • diet

  • endothelium

  • gluten

  • gut-vascular barrier

  • plasmalemma vesicle-a...

Web of Science© citazioni
0
Data di acquisizione
Jun 9, 2022
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