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Genetic studies of body mass index yield new insights for obesity biology

Locke, Adam E
•
Kahali, Bratati
•
Berndt, Sonja I.
altro
GASPARINI, PAOLO
2015
  • journal article

Periodico
NATURE
Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
DOI
10.1038/nature14177
WOS
WOS:000349190300031
Archivio
http://hdl.handle.net/11368/2833807
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84923171580
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2833807
Soggetti
  • Adipogenesi

  • Adiposity

  • Age Factor

  • Continental Populatio...

  • Energy Metabolism

  • Europe

  • Female

  • Genetic Predispositio...

  • Glutamic Acid

  • Human

  • Insulin

  • Male

  • Obesity

  • Polymorphism, Single ...

  • Quantitative Trait Lo...

  • Synapse

  • Body Mass Index

  • Genome-Wide Associati...

  • Multidisciplinary

Scopus© citazioni
2388
Data di acquisizione
Jun 15, 2022
Vedi dettagli
Web of Science© citazioni
2914
Data di acquisizione
Mar 20, 2024
Visualizzazioni
4
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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