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Epidemiology, species distribution, antifungal susceptibility, and outcome of Candidemia across five sites in Italy and Spain

BASSETTI, MATTEO
•
MERELLI, Maria
•
Righi, Elda
altro
Tumbarello, Mario
2013
  • journal article

Periodico
JOURNAL OF CLINICAL MICROBIOLOGY
Abstract
Candidemia has become an important bloodstream infection that is frequently associated with high rates of mortality and morbidity, and its growing incidence is related to complex medical and surgical procedures. We conducted a multicenter study in five tertiary care teaching hospitals in Italy and Spain and evaluated the epidemiology, species distribution, antifungal susceptibilities, and outcomes of candidemia episodes. In the period of 2008 to 2010, 995 episodes of candidemia were identified in these hospitals. The overall incidence of candidemia was 1.55 cases per 1,000 admissions and remained stable during the 3-year analysis. Candida albicans was the leading agent of infection (58.4%), followed by Candida parapsilosis complex (19.5%), Candida tropicalis (9.3%), and Candida glabrata (8.3%). The majority of the candidemia episodes were found in the internal medicine department (49.6%), followed by the surgical ward, the intensive care unit (ICU), and the hemato-oncology ward. Out of 955 patients who were eligible for evaluation, 381 (39.9%) died within 30 days from the onset of candidemia. Important differences in the 30-day mortality rates were noted between institutions: the lowest mortality rate was in the Barcelona hospital, and the highest rate was in the Udine hospital (33.6% versus 51%, respectively; P.0.0005). Overall, 5.1% of the 955 isolates tested were resistant or susceptible dose dependent (SDD) to fluconazole, with minor differences between the hospitals in Italy and Spain (5.7% versus 3.5%, respectively; P.0.2). Higher MICs for caspofungin were found, especially with C. parapsilosis complex (MIC90, 1 .g/ml). Amphotericin B had the lowest MICs. This report shows that candidemia is a significant source of morbidity in Europe, causing a substantial burden of disease and mortalit
DOI
10.1128/JCM.01998-13
WOS
WOS:000327147100044
Archivio
http://hdl.handle.net/11390/1101159
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84889812043
http://jcm.asm.org/content/51/12/4167.full.pdf+html
Diritti
closed access
Soggetti
  • Adult

  • Aged

  • Aged, 80 and over

  • Antifungal Agent

  • Candida

  • Candidemia

  • Female

  • Hospitals, Teaching

  • Human

  • Incidence

  • Italy

  • Male

  • Microbial Sensitivity...

  • Middle Aged

  • Spain

  • Survival Analysi

  • Tertiary Care Center

  • Treatment Outcome

  • Microbiology (medical...

Scopus© citazioni
165
Data di acquisizione
Jun 7, 2022
Vedi dettagli
Web of Science© citazioni
173
Data di acquisizione
Mar 27, 2024
Visualizzazioni
3
Data di acquisizione
Apr 19, 2024
Vedi dettagli
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