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The importance of size-exclusion characteristics of type I collagen in bonding to dentin matrices.

Takahashi M
•
Nakajima M
•
Tagami J
altro
Pashley DH
2013
  • journal article

Periodico
ACTA BIOMATERIALIA
Abstract
The mineral phase of dentin is located primarily within collagen fibrils. During development, bone or dentin collagen fibrils are formed first and then water within the fibril is replaced with apatite crystallites. Mineralized collagen contains very little water. During dentin bonding, acid-etching of mineralized dentin solubilizes the mineral crystallites and replaces them with water. During the infiltration phase of dentin bonding, adhesive comonomers are supposed to replace all of the collagen water with adhesive monomers that are then polymerized into copolymers. The authors of a recently published review suggested that dental monomers were too large to enter and displace water from collagen fibrils. If that were true, the endogenous proteases bound to dentin collagen could be responsible for unimpeded collagen degradation that is responsible for the poor durability of resin-dentin bonds. The current work studied the size-exclusion characteristics of dentin collagen, using a gel-filtration-like column chromatography technique, using dentin powder instead of Sephadex. The elution volumes of test molecules, including adhesive monomers, revealed that adhesive monomers smaller than ∼1000Da can freely diffuse into collagen water, while molecules of 10,000Da begin to be excluded, and bovine serum albumin (66,000Da) was fully excluded. These results validate the concept that dental monomers can permeate between collagen molecules during infiltration by etch-and-rinse adhesives in water-saturated matrices.
DOI
10.1016/j.actbio.2013.07.037
WOS
WOS:000328592600027
SCOPUS
2-s2.0-84887157232
Archivio
http://hdl.handle.net/11368/2720700
Diritti
metadata only access
Soggetti
  • dentin bonding agent

Scopus© citazioni
46
Data di acquisizione
Jun 7, 2022
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Web of Science© citazioni
58
Data di acquisizione
Mar 23, 2024
Visualizzazioni
1
Data di acquisizione
Apr 19, 2024
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