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N-isopropyl chitosan. A pH- and thermo-responsive polysaccharide for gel formation

Cok M.
•
Viola M.
•
Vecchies F.
altro
Donati I.
2020
  • journal article

Periodico
CARBOHYDRATE POLYMERS
Abstract
The present contribution deals with the synthesis and characterization of N-isopropyl chitosan in which the introduction of hydrophobic groups leads to an increased flexibility of the polysaccharide backbone. The isopropyl groups extend the solubility of the modified-chitosan samples and render the modified chitosan a pH- and thermo-sensitive system for hydrogel formation. Indeed, upon varying the pH of the system and/or its temperature within a range compatible with biological applications, a non-reversible sol-gel transition occurs, as determined through extended rheological analyses. The modified chitosan samples show a very good biocompatibility as determined through preliminary viability and cell growth experiments.
DOI
10.1016/j.carbpol.2019.115641
WOS
WOS:000504402300063
SCOPUS
2-s2.0-85075902629
Archivio
http://hdl.handle.net/11368/2960825
https://www.sciencedirect.com/science/article/pii/S0144861719313098?via=ihub
Diritti
closed access
FVG url
https://arts.units.it/request-item?handle=11368/2960825
Soggetti
  • Hydrogel formation

  • N-isopropyl modified ...

  • pH-stimulus

  • Rheology

  • Thermal stimulus

Web of Science© citazioni
12
Data di acquisizione
Jun 13, 2022
Scopus© citazioni
12
Data di acquisizione
Jun 14, 2022
Vedi dettagli
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