Ruolo
Docenti di ruolo di IIa fascia
Qualifica (ricerca)
Professori Associati
 
Area Ministeriale
AREA MIN. 03 - Scienze chimiche
Macro-settore concorsuale
03/C - ORGANICO,INDUSTRIALE
Academic SSD
Settore CHIM/06 - Chimica Organica
Short CV

Prof. Patrizia Nitti Casini (Trieste 09/14/58), received the Doctor degree in Chemistry in 1984 (110/110 cum laude) at the University of Trieste. From 1985 to 1988 she was in charge with the Mass Spectrometry Laboratory, in cooperation with prof. Traldi of the CNR of Padua. She became Researcher in Chemistry in 1990 and Associate professor in 2001 at the University of Trieste. As to her research interests, she studied the diastereoselective formation of carbon-carbon single bonds through the reactions of enamines with activated electrophiles, integrating the synthesis with the relative stereochemical studies. A parallel research was devoted to the synthesis of enantiopure molecules having biological activity, by the use of purified enzymes and whole cell systems. This research was integrated with chirooptial studies and molecular modeling in cooperation with other researchers. Recently, the enantioselective synthesis of hydroxystearic acids by olefinic metathesis processes, has been investigated. She is reviewer for the scientific journals Applied Microbiology and Biotechnology, Green Chemistry, Current Organic Synthesis, Current Catalysis, Journal of Organic Chemistry, Chirality, Journal of Molecular Catalysis B: Enzymatic, Research on Chemical Intermediates, Molbank, Molecules, Current Organic Chemistry and Journal of Molecular Structure. She has participated in over 80 national and international conferences with poster and oral communications. Prof. Nitti has published 81 papers in collaboration with other authors and a review entitled “Recent aspects of the synthesis of enantiopure 5-oxo-tetrahydro-3-furancarboxylic acids” in Targets in Heterocyclic System, Chemistry and Properties, O.A. Attanasi e D. Spinelli ed., 1999, vol 3.

Prof. Patrizia Nitti Casini (Trieste 09/14/58), received her degree (110/110 cum laude) in Chemistry in 1984 at the University of Trieste. From 1985 to 1988 she had a contract with the Faculty of Pharmacy of the University of Trieste to work with a VG 7070 mass spectrometer. In 1986 she obtained the Chemistry Teacher Certification for the secondary school. Assistant professor in 1990 at the University of Trieste, in 2001 she became associate professor in organic chemistry in the Faculty of Sciences of the same University. From 2011 to 2015 she has been coordinator of PAS (Percorsi Abilitanti Speciali, Educational path for teacher certification) for the chemical classes A012, A013, C240 and C350 and coordinator of TFA (Tirocinio Formativo Attivo, Active training internship for teacher certification) for the chemical/biological classes A060 and A013. Since 2013 she is referent of the Department of Chemical and Pharmaceutical Sciences at the CIRD (Interdipartimental Center for Didactic Research). Since November 2017 she has been a member of the PF24 (Percorso formativo 24 CFU) Commission. Since 2018 she has been referent for the science project of the Polo of Trieste "I Lincei per una nuova didattica nella scuola: una rete nazionale" for the Department of Chemical and Pharmaceutical Sciences. The research interests of Prof. Nitti have been in the formation of carbon-carbon single bonds by reactions of enamines or enolates with nitroolefins. Due to the versatility of the nitro group, the nitroalkylated compounds obtained were subsequently transformed. For example 1,2-oxazine-N-oxides were obtained, which, hydrolysed under acidic conditions, furnished 1,2-dicarbonyl derivatives; nitrodienes were obtained from the reaction of Fischer’s base with nitro vinyl ethers; optical active nitro ketones were synthesised from chiral enamino sulphones. In the context of the study of organocatalytic reactions for the production of functionalized heterocyclic systems, the synthesis of chiral non racemic 1,4-dihydropyridazine by reaction of 1,2-diaza-1,3-dienes with arylacetaldehydes in the presence of L-proline as an organocatalyst was investigated. The reaction between nitroolefins and 1,2-dicarbonyl compounds to obtain chiral non racemic alpha-ketols using different catalysts, including (S) - (-) and (R) - (+) - 1-phenylethylamine and L-proline, was also studied In the field of biotransformations the syntheses of enantiomerically enriched lactones and lactams have been studied. In fact, this sub-unit is part of a variety of naturally occurring compounds isolated from insects, plants, fungi and sea organisms. Among biologically active gamma-lactones, paraconic acid, which are characterized by a carboxy group at beta position, have shown antibiotic and antitumor activity. Furthermore, gamma-lactones bearing a hydroxymethyl group at C-beta are involved in the production of interesting secondary metabolites. Chemoenzymatic methods have been used for the obtainment of these classes of compounds in enantiomerically enriched form. Usually, hydrolytic enzymes such as esterases, lipases and proteases are used for kinetic enzymatic resolutions of these systems, but also bioreductions with baker’s yeast (Saccharomyces cerevisiae) or other yeasts of suitable precursors have yielded good results. Recently, the enantioselective synthesis of hydroxystearic acids by olefinic metathesis processes, has been investigated. Hydroxystearic acids and their derivatives are starting materials for a series of industrial products such as cosmetics, resins, paints, lubricants, biopolymers, biodiesel and find important applications in the biological field as constituents of FAHFA (Fatty Acid ester of Hydroxy Fatty Acid) She is reviewer for the scientific journals Applied Microbiology and Biotechnology, Green Chemistry, Current Organic Synthesis, Current Catalysis, Journal of Organic Chemistry, Chirality, Journal of Molecular Catalysis B: Enzymatic, Research on Chemical Intermediates, Molbank, Molecules, Current Organic Chemistry and Journal of Molecular Structure She has participated in over 80 national and international conferences with poster and oral communications. Prof. Nitti has published 81 papers in collaboration with other authors and a review entitled “Recent aspects of the synthesis of enantiopure 5-oxo-tetrahydro-3-furancarboxylic acids” in Targets in Heterocyclic System, Chemistry and Properties, O.A. Attanasi e D. Spinelli ed., 1999, vol 3.