Ruolo
Docenti di ruolo di Ia fascia
Qualifica (ricerca)
Professori Ordinari
 
Area Ministeriale
AREA MIN. 09 - Ingegneria industriale e dell'informazione
Macro-settore concorsuale
09/D - INGEGNERIA CHIMICA E DEI MATERIALI
Settore SSD
Settore ING-IND/24 - Principi di Ingegneria Chimica
Short CV

November 19th 2005 associate professor (AP) (Ing. Ind. 24) Trieste University. November 19th 2008 confirmation in the role of AP (Ing/Ind 24). January 29th 2014 scientific abilitation for the full professor role (Ing/Ind 24). TEACHING “Macromolecular Materials Engineering" (Ing. Ind. 22), “Diffusive processes in complex media” (Ing. Ind. 24), “Process simulation” (Ing. Ind. 24). “Theory and development of chemical processes” (Ing. Ind. 26) “Principles of tissue engineering and biomaterials – Materials module” (Ing. Ind 22) “Structure and properties of complex systems/B” (Ing. Ind. 22) Since May 2nd 2013 President of the Master Degree in Process (LM-53) and Materials Engineering (LM-22). “Transport Phenomena” (Ing. Ind. 24) RESEARCH: 156 papers, 154 abstracts, 12 book chapters and one book (3312 citations, H-index 32). Associate Editor of CABEQ and Int. J. of Adv. Sci. and Eng.. FUNDING 1) FONDO TRIESTE 2006 (February 1st 2007 – February 1st 2009): 150000 € 2) LLOYD PHARMA (Third parties; October 2009 – December 2009): 2400 € 3) PMI (PN) (Third parties; May 2013 – June 2015): 8500 € 4) AZAD-PHARMA (CH) (Third parties; November 2010 – December 2016): 144000 € 5) VIVABIOCEL S.p.A. (UD) (Third parties; June 2015): 3600 € 6) PRIN 2008 (2008HCAJ9T; March 22nd 2010 – September 22nd 2012): 42474 € 7) CRO-Aviano (PN) (PhD grant; December 21st 2012 – December 31st 2015): 96960 € 8) PRIN 2010-11 (2008HCAJ9T; February 1st 2013 – February 1st 2016): 178625 € 9) CRO-Aviano (PN) (PhD grant; May 19th 2015 – December 31st 2018): 52579 € 10) FRA 2016 (January 01th 2017 – December 31st 2018): 11250 € 11) POR-FESR 1.3b Standard 2016 BIOFLUO (April 1st 2017 – March 31st 2018): 103805.4 € 12) AREA Science Park “MADE in TRIESTE” (March 01th 2018 – February 28th 2019): 24000 € 13) AEP Polymers Srl (TS) (Third parties; January 16 – March 16 2019): 2030 € PATENTS 1) Italian Industrial patent # 102016000060004, December 17th 2018

CAREER Mario Grassi was born in Genova (Italy) on July 18th 1964 and he lives in Trieste (Italy), via Commerciale 47/5. He got his high school degree (scientific field) at the Liceo Scientifico "G. Galilei" in Trieste (52 / 60) on July 29th 1983. He got his five years graduate degree in Chemical Engineering on April 10th (110/110 cum laude) at the Trieste University defending a thesis entitled "Studio della diffusione in idrogeli di biopolimeri per la progettazione di sistemi farmaceutici a rilascio controllato" (Study on diffusion in biopolymeric hydrogels for the designing of pharmaceutical controlled release systems). He got his working abilitation on April 1991 at the University of Trieste. He has been employee of Diesel Ricerce (Fincantieri group, most important Italian ship builder) (January 1992 - January 1993). He got his Ph.D. degree in Chemical Engineering at the Padova University (Italy) on December 13rd 1996 defending a thesis on "Diffusione di principi attivi in matrici gel polimeriche di impiego farmaceutico" (Drug diffusion in polymeric gel matrices used in the pharmaceutical field). He got a one-year grant (1996) from the Physical Pharmacy Laboratory of Vectorpharma Trieste (pharmaceutical industry dealing with the improvement of poorly bioavailable drug) in order to study diffusion processes and drug activation by means of mechano-chemical activation. He got a Post Doct. grant (December 12th 1996 - December 12th 1998) from the Department of Chemical Engineering (DICAMP) (Trieste University) in order to study from an experimental and theoretical view point drug diffusion in polymeric matrices and release processes. Particular care was devoted to the study of viscoelastic and rheological properties of polymeric systems. He got a four years grant (Assegno di ricerca - Research check) (January 25th 1999 - January 25th 2003) at the Department of Chemical, Environmental and Raw Materials Engineering in order to experimentally and theoretically studying drug release process from different kinds of release systems (polymeric matrices and mini-matrices). The attention was focused on mass transport, thermodynamic and the relation existing among mass diffusion and rheological characteristics of the polymeric network. 2003-2004 he has been employee of EURAND (Pharmaceutical Industry dealing with the improvement of poorly bioavailable drugs) as coordinator of the Trieste site research activities. In the Academic years 2001/2002, 2002/2003, 2003/2004 and 2004/2005 he has been consultant professor for the Department of Materials Engineering (DIMCA) of the University of Trieste, detached site of Pordenone, teaching "Macromolecular Materials Engineering" (Ing. Ind. 22). This course dealt with the rheological properties of melt polymers and the study of those processes using this information (extrusion, injection molding, termoforming and so on). On November 19th 2005 he became associate professor (Ing. Ind. 24) at the Faculty of Engineering of the Trieste University. On November 19th 2008 he got the confirmation in the role of associate professor (SSD Ing/Ind 24). On January 29th 2014 he got the scientific abilitation for the full professor role (SSD Ing/Ind 24). DIDACTIC ACTIVITY Bachelor and Master degree In the academic years 2001/2002 – 2004/2005 he taught, as consultant professor, “Macromolecular Materials Engineering" (Ing. Ind. 22), Faculty of Engineering, Trieste University detached site of Pordenone. In the academic years 2005/2006 – 2008/2009 he taught “Macromolecular Materials Engineering" (Ing. Ind. 22), Faculty of Engineering, Trieste University detached site of Pordenone. In the academic years 2006/2007 – 2010/2011 he taught “Diffusive processes in complex media” (Ing. Ind. 24), Faculty of Engineering, Trieste University. Since the academic year 2006/2007 he has taught “Process simulation” (Ing. Ind. 24), Faculty/Department of Engineering, Trieste University. In the academic year 2009/2010 he taught “Theory and development of chemical processes” (Ing. Ind. 26), Faculty of Engineering, Trieste University. In the academic years 2010/11 and 2011/2012 he taught “Principles of tissue engineering and biomaterials – Materials module” (Ing. Ind 22), Faculty of Medicine – Master degree in Biotechnology, Trieste University. In the academic years 2010/11 – 2015/16 and since academic year 2017-2018 he has taught “Structure and properties of complex systems/B” (Ing. Ind. 22), Department of Engineering, Trieste University. Since the academic year 2016/2017 has has taught “Transport Phenomena” (Ing. Ind. 24), Department of Engineering and Architecture, Trieste University. He has been mentor of 21 Master degree theses and 10 Bachelor degree theses. PhD In the period January 1st 2002 – June 1st 2006 he has been member of the Board of the Doctorate in Engineering and Materials Science. Since 21/07/2006 he has been member of the board of the Doctorate School in Chemical and Pharmaceutical Sciences and Technologies (now Doctorate in Chemistry). In the period 2012 – 2015 he was vice-chairmen of the same School. Since the academic year 2015-2016 he has teached “Mathematical Modelling in Biopharmaceutics” in the frame of the PhD educational activities. Since January 2013 he has been member of the Department Board of the Department of Engineering and Architecture, Trieste University. He has been mentor of 6 PhD theses and co-mentor of 5 PhD theses. Other commitments In the period January 1st 2013 – October 31st 2018 he has been member of the board of the Department of Engineering and Architecture. Since May 2nd 2013 he has been President of the Master Degree (Laurea Magistrale Interclasse, IN-17) in Process (LM-53) and Materials Engineering (LM-22). He has been Erasmus responsible for the master course in Process and Materials Engineering for the sites of Yildiz, Copenaghen, and he is responsible for the sites of Graz and Saragozza. SCIENTIFIC RESEARCH ACTIVITY Editorial activity He currently acts as referee for many international journals such as Journal of Pharmaceutical Sciences, Pharmaceutical Research, International Journal of Pharmaceutics, European Journal of Pharmaceutical Sciences, European Journal of Pharmaceutics and Biopharmaceutics, Fluid Phase Equilibria, Journal of Controlled Release, Journal of Membrane Science, Journal of Applied Polymer Science, Journal of Pharmacy and Pharmacology, AICHEJ, Chemical Engineering Science, PLOS ONE and Expert Opinion in Drug Delivery. He has been guest Editor of Current Pharmaceutical Biotechnology (special issue on “Nucleic acid based drug as novel therapeutics in the treatment of human disease”, 5(4), 2004, Grassi G. and Grassi M. editors). Member of the organizing committee of the XI Symposium of the Italian Society of Rheology (SIR), Trieste (IT), May 23 – 26, 2010. In the period 2011 – 2015 he was member of the board of the international journal “World Journal of Pharmacology”. Since 2011 he has been member of the editorial board of the international journal “Chemical and Biochemical Engineering Quarterly (CABEQ)”. Member of the scientific committee of the XII Symposium of the Italian Society of Rheology (SIR), Ustica (PA, IT), July 3 – 6, 2012. Since May 2013 he has been Associate Editor of the international journal “Chemical and Biochemical Engineering Quarterly (CABEQ). Member of the scientific committee of the XIII Symposium of the Italian Society of Rheology (SIR), Brescia (IT), September 7 – 10, 2014. Since January 2014 he has been Associate Editor of the international journal “International Journal of Advanced Science and Engineering”. Member of the scientific and organizing committee of the IAPC-4 Meeting, Red island, Rovinj (HR), September 21 - 24, 2015. He has been guest Editor of Current Drug Delivery (special issue on “New trends in gene therapy: multidisciplinary approaches to siRNAs controlled delivery” 2016). He has been guest Editor of International Journal of Pharmaceutics (special issue on “Novel applications of hydrogels in pharmaceutical and biomedical sciences” 2019). Scientific associations He is member of the Italian Society of Rheology (SIR), of the European Society of Rheology, of the Controlled Release Society (Italian Chapter) and of DRITELF (Association of Italian professors and researchers of Pharmaceutical Technologies and Legislation). In the period 2010-2015 he has been member of the board of the “Associazione italiana di reologia” (SIR). In the period 2014-2016 he has been member of the “Proboviri Council” of the Controlled Release Society (Italian Chapter). PUBLICATIONS He is authors/co-author of 157 papers published on international journals, 154 abstracts presented in national and international Symposia, 12 book chapters and one book (3312 citations, H-index 32). At present, his research field is about a) modeling of drug release from delivery systems and drug absorption by living tissues, b) characterization (rheology/Low field NMR/release tests) of polymer based delivery systems and drugs for what concerns nano-crystals peculiar properties and c) characterization, by means of Low Field NMR, of the sputum of patients affected by chronic obstructive pulmonary diseases Papers 1) “Controlled release of theophylline from water-swollen scleroglucan matrices”; Adrover, M. Giona, M. Grassi, R. Lapasin, S. Pricl Journal of Membrane Science, 113, 7-20, 1996. 2) “Analysis of controlled release in disordered structures: a percolation model”; Adrover, M. Giona, M. Grassi Journal of Membrane Science, 113, 21-30, 1996. 3) “Apparent non-fickian release from a scleroglucan gel matrix”; Grassi, R. Lapasin, S. Pricl, I. Colombo Chemical Engineering Communications, 155, 89-112, 1996. 4) “A study of the rheological behavior of scleroglucan weak gel systems”; M. Grassi, R. Lapasin, S. Pricl Carbohydrate Polymers, 29, 169-181, 1996. 5) “Modeling phase transitions and sorption-desorption kinetics in thermo-sensitive gels for controlled drug delivery systems”; Colombo, M. Fermeglia, M. Grassi, R. Lapasin, S. Pricl Fluid Phase Equilibria, 116, 148-161, 1996. 6) “Rheological modeling of fractal and dense suspensions”; M. Grassi, R. Lapasin, S. Pricl The Chemical Engineering Journal, 64, 99 - 106, 1996. 7) “Determination of the drug diffusion coefficient in swollen hydrogel polymeric matrices by means of the inverse sectioning method”; Colombo, M. Grassi, R. Lapasin, S. Pricl Journal of Controlled Release, 47, 305 - 314, 1997. 8) “Synergistic gelation of xanthan gum with locust bean gum: a rheological investigation”; G. Copetti, M. Grassi, R. Lapasin, S. Pricl Glycoconjugate Journal, 14, 951 - 961, 1997. 9) “Modeling of drug release from a swellable matrix”; M. Grassi, R. Lapasin, S. Pricl Chemical Engineering Communications, 169, 79 - 109, 1998. 10) “Modelling of solute transport across a temperature-sensitive polymer membrane”; M. Grassi, S. H. Yuk, S. H. Cho Journal of Membrane Science, 152, 241-249, 1999. 11) “Permeazione di acyclovir attraverso la mucosa intestinale di ratto: esperimenti in vitro e modellizzazione matematica”, M. Grassi, N. Coceani, G. Cadelli, P. Esposito Bollettino Chimico Farmaceutico, 138(3), 121-128, 1999. 12) “Mathematical modelling of drug permeation through a swollen membrane”, M. Grassi, I. Colombo, Journal of Controlled Release, 59, 343-359, 1999. 13) “The effect of drug dissolution on drug release from swelling polymeric matrices: mathematical modeling”; M. Grassi, R. Lapasin, S. Pricl Chemical Engineering Communications, 173, 147 - 173, 1999. 14) “Novel hydrogel system from scleroglucan: synthesis and characterization”, T. Coviello, M. Grassi, G. Rambone, E. Santucci, M. Carafa, E. Murtas, F. M. Riccieri, F. Alhaique, Journal of Controlled Release, 60, 367 – 378, 1999. 15) “A combination of vapor sorption and laser light scattering methods for the determination of the Flory parameter  and the crosslink density of a polymeric microgel”, F. Mantovani, M. Grassi, I. Colombo, R. Lapasin, Fluid Phase Equilibria, 167(1), 63 - 81, 2000. 16) “Release of a model drug from different powdered polymeric carriers”, M. Grassi, Bollettino Chimico Farmaceutico International, 1, 26 - 33, 2000. 17) “Mathematical modeling of drug release from microemulsions: theory in comparison with experiments”, M. Grassi, N. Coceani, L. Magarotto. Journal of Colloid and Interface Science, 228(1), 141 – 150, 2000. 18) “Drug release from an ensemble of swellable crosslinked polymer particles”, M. Grassi, I. Colombo, R. Lapasin, Journal of Controlled Release, 68(1), 97-113, 2000. 19) “A crosslinked system from Scleroglucan derivative: preparation and characterization” T. Coviello, M. Grassi, G. Rambone, F. Alhaique, Biomaterials, 22, 1899 – 1909, 2001. 20) “Effects of polymer addition on the rheology of O/W microemulsions” R. Lapasin, M. Grassi, N. Coceani, Rheological Acta, 40(2), 185 –192, 2001. 21) “Experimental determination of the theophylline diffusion coefficient in swollen sodium-alginate membranes”, M. Grassi, I. Colombo, R. Lapasin, Journal of Controlled Release, 76(1-2), 93 – 105, 2001. 22) “Theoretical considerations on in vivo intestinal permeability determination by means of the single pass and recirculating techniques”, M. Grassi, G. Cadelli, Internationl Journal of Pharmaceutics, 229(1), 95 – 105, 2001. 23) “Selection and Characterization Active Hammerhead Ribozymes Targeted Against Cyclin E and E2F1 Full-Length mRNA”, G. Grassi, A. Kuhn, M. Grassi, G. Bauriedel, R. Kandolf, Antisense and Nucleic Acid Drug Development, 11, 271 - 287, 2001. 24) “Modeling of drug release from poly-disperse microencapsulated spherical particles”, C. Sirotti, I. Colombo, M. Grassi, Journal of Microencapsulation, 19(5), 603-614, 2002. 25) “Modeling of drug release from microemulsions: a peculiar case”, C. Sirotti, N. Coceani, I. Colombo, R. Lapasin, M. Grassi, Journal of Membrane Science, 204 (1-2), 401 – 412, 2002. 26) “Determination of Hammerhead ribozyme kinetic constants at high molar ratio ribozyme-substrate”, G. Grassi, M. Grassi, A. Kuhn, R. Kandolf, Journal of Mathematical Biology, 45, 261-277, 2002. 27) “Modelling partitioning of sparingly soluble drugs in a two phase liquid system”, M. Grassi, N. Coceani, L. Magarotto, International Journal of Pharmaceutics, 239 (1), 157 – 169, 2002. 28) “Acyclovir permeation through rat skin: mathematical modelling and in vitro experiments”, M. Grassi, N. Coceani, I. Colombo, International Journal of Pharmaceutics, 254(2), 197- 210, 2003. 29) “Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system”, M. Grassi, D. Voinovich, M. Moneghini, E. Franceschinis, B. Perissutti, J. Filipovic-Grcic, Journal of Controlled Release, 88(3), 381-391, 2003. 30) “Scleroglucan/borax: characterization of a novel hydrogel system suitable for drug delivery”, T. Coviello, M. Grassi, R. Lapasin, A. Marino, F. Alhaique, Biomaterials, 24, 2789-2798, 2003. 31) “Thermal Modeling of a Vibrational Mill” J. M. Castillo, R. Lapasin, M. Grassi, Industrial & Engineering Chemistry Research, 42, 2015-2021, 2003. 32) “Characterization of a Quaternary Liquid System Improving the Bioavailabilty of Poorly Water Soluble Drugs" F. Meriani; N. Coceani; C. Sirotti; D. Voinovich; M. Grassi, Journal of Colloid and Interface Science, 263(2), 590-596, 2003. 33) “Structural and rheological characterization of scleroglucan/borax hydrogel for drug delivery” T. Coviello, G. Coluzzi, A. Palleschi, M. Grassi, E. Santucci, F. Alhaique, International Journal of Biological Macromolecules, 32, 83-92, 2003. 34) “Theoretical and experimental study on theophylline release from stearic acid cylindrical delivery systems” M. Grassi, D. Voinovich, M. Moneghini, E. Franceschinis, B. Perissutti, J. Filipovic-Grcic, Journal of Controlled Release, 92(3), 275-289, 2003. 35) “Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human gliobastoma cell line U87” G. Grassi, P. Maccaroni, R. Meyer1, H. Kaiser1, E. D’Ambrosio, E. Pascale, M. Grassi, A. Kuhn, P. Di Nardo, R. Kandolf and J-H Küpper, Carcinogenesis, 24, 1625 – 1635, 2003. 36) “In vitro nimesulide absorption from different formulations” F. Meriani, N. Coceani, C. Sirotti, D. Voinovich, M. Grassi, Journal of Pharmaceutical Sciences, 93(3), 540-552, 2004. 37) “Preparation and in vivo-in vitro characterisation of a melt pelletised paracetamol/stearic acid sustained release delivery system” M. Grassi, D. Voinovich, E. Franceschinis, B. Perissutti, J. Filipovic-Grcic, Spectroscopy, an International Journal, 18(2), 375-386, 2004. Paper presented at the Second Conference on Spectroscopy in Biomedical Sciences, London, 5-8 Luglio 2003. 38) “Modeling of drug release from partially coated matrices of high viscosity HPMC”, M. Grassi, L. Zema, M. E. Sangalli, A. Maroni, F. Giordano, A. Gazzaniga. International Journal of Pharmaceutics, 276, 107-114, 2004. 39) “Therapeutic potential of hammerhead ribozymes in the treatment of hyper-proliferative diseases”, G. Grassi, P. Dawson, G. Guarnieri, R. Kandolf, M. Grassi. Current Pharmaceutical Biotechnology, 5(4), 369 -386, 2004. 40) “Mathematical modelling and controlled drug delivery: matrix systems”, M. Grassi, G. Grassi. Current Drug Delivery, 2(1), 97-116, 2005. 41) “Scleroglucan: a versatile polysaccharide for modified drug delivery”, T. Coviello , A. Palleschi, M. Grassi, P. Matricardi, G. Bocchinfuso, F. Alhaique . Molecules, 10, 643-656, 2005. 42) “Self-emulsifying pellets prepared by wet granulation in high-shear mixer: influence of formulation variables and preliminary study on the in vitro absorption”, E. Franceschinis, D. Voinovich, M. Grassi, B. Perissutti, J. Filipovic-Grcic, A. Martinac, F. Meriani-Merlo. International Journal of Pharmaceutics, 291, 87-97, 2005. 43) “A new polysaccharidic gel matrix for drug delivery: preparation and mechanical properties”, T. Coviello, F. Alhaique, C. Parisi, P. Matricardi, G. Bocchinfuso, M. Grassi, Journal of Controlled Release, 102, 643-656, 2005. 44) “A new Scleroglucan/borax hydrogel: swelling and drug release”, T. Coviello, M. Grassi, A. Palleschi, G. Bocchinfuso, G. Coluzzi, F. Banishoeib, F. Alhaique. International Journal of Pharmaceutics, 289, 97-107, 2005. 45) “Temperature-Sensitive Hydrogels: Potential Therapeutic Applications”, G. Grassi, R. Farra, P. Caliceti, G. Guarnieri, S. Salmaso, M. Carenza, M. Grassi. American Journal of Drug Delivery, 3(4), 239 – 251, 2005. 46) “Preparation of Theophylline-Hydroxypropylmethylcellulose Matrices Using Supercritical Antisolvent Precipitation”, M. Moneghini, I. Kikic, M. Grassi, B. Perissutti, A. Cortesi, F. Princivalle. Drug Development and Industrial Pharmacy, 32, 39-52, 2006. 47) “Rheological properties of aqueous pluronic-alginate systems containing liposomes” G. Grassi, A. Crevatin, R. Farra, G. Guarnieri, A. Pascotto, B. Rehimers, R. Lapasin, M. Grassi. Journal of Colloids and Interface Science. 301, 282-290, 2006. 48) “Potential applications of small interfering RNAs in the cardiovascular field” F. Agostini, B. Dapas, R. Farra, M. Grassi, G. Racchi, K. Klingel, R. Kandolf, O. heindenreich, A. Mercatanti, G. Rainaldi, N. Altamura, G. Guarnieri, G. Grassi. Drugs of the Future. 31(6), 513-525, 2006. 49) “Propaedeutic study for the delivery of nucleic acid based molecules from PLGA microparticles and Stearic acid nanoparticles” G. Grassi, N. Coceani, R Farra, B. Dapas, G. Racchi, N. Fiotti, A. Pascotto, B. Rehimers, G. Guarnieri, M. Grassi. International Journal of Nanomedicine, 1(4), 523-533, 2006. 50) “Two Galactomannans and Scleroglucan as Matrices for Drug Delivery: Preparation and Release Studies” T. Coviello, F. Alhaique, A. Dorigo, P. Matricardi, M. Grassi, European Journal of Pharmaceutics and Biopharmaceutics, 66, 200-209, 2007. 51) “Effects of Various Promoter Derived Sequences on the Cleavage Kinetic of an Hammerhead Ribozyme Directed Against Cyclin E1 mRNA” J. Platz, M. Grassi, A. Kuhn, R. Kandolf, G. Racchi, R. Farra, B. Dapas, N. A. Pascotto, C. Giansante, N. Fiotti, G. Guarnieri and G. Grassi. Drug Metabolsim Letter, 1(3), 218-225, 2007. 52) “Characterisation of nucleic acid molecule/liposome complexes and rheological effects on pluronic/alginate matrices”. Grassi G, Farra R, Noro E, Voinovich D, Lapasin R, Dapas B, Alpar O, Zennaro C, Carraro M, Giansante C, Guarnieri G, Pascotto A, Rehimers B, Grassi M. Journal of drug delivery science and technology, 2007, 17(5), 325-331. 53) “Theoretical and experimental characterisation of stearic acid based sustained release devices obtained by hot melt co-extrusion” U. Quintavalle, D. Voinovich, B. Perissutti, F. Serdoz, M. Grassi. Journal of drug delivery science and technology, 2007, 17(6), 415-420. 54) “Mechanical and diffusive properties of homogeneous alginate gels in form of particles and cylinders” E. Pasut, R. Toffanin, D. Voinovich, C. Pedersini, E. Murano, M. Grassi, Journal of Biomedical Materials Research: Part A, 2008, 87A(3) 819-824. 55) “Bi-layered self-emulsifying pellets prepared by co-extrusion and spheronization: influence of formulation variables and preliminary study on the in vivo absorption” T. Iosio, D. Voinovich, M.Grassi, J. F. Pinto, B. Perissutti, M. Zacchigna, U. Quintavalle, F. Serdoz. European Journal of Pharmaceutics and Biopharmaceutics, 2008, 69(2), 686-697. 56) “Preparation of sustained release co-extrudates by hot melt extrusion and mathematical modelling of in vitro/in vivo drug release profiles” U. Quintavalle, D. Voinovich, B. Perissutti, F. Serdoz, G. Grassi, A. Dal Col, M. Grassi. European Journal of Pharmaceutical Sciences, 2008, 33, 282-293. 57) “Sustained-release solid dispersions of ibuprofen prepared by microwave irradiation” M. Moneghini, N. De Zordi, M. Grassi, G. Zingone. Journal of drug delivery science and technology, 2008, 18(5), 327-333. 58) “Mathematical modelling of NABD release from endoluminal gel paved stent”, L. Davia, G. Grassi, G. Pontrelli, R. Lapasin, D. Perin, M. Grassi. Computational Biology and Chemistry, 2009, 33, 33-40. 59) “Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels”, D Baiz, G Pozzato, B Dapas, R Farra, B Scaggiante, M Grassi, L Uxa, C Giansante, C Zennaro, G Guarnieri and G Grassi. Biochimie 91, 373-382, 2009. 60) “Novel design of drug delivery in stented arteries: A numerical comparative study”, M. Grassi, G. Pontrelli, L. Teresi, G. Grassi, L. Comel, A Ferluga, L. Galasso, Mathematical Biosciences and Engineering, 2009, 6(3), 493-508. 61) “Synthesis and Spontaneous Polymerization of Oligo(ethylene glycol)-Conjugated Benzofulvene Derivatives: a Polymer Brush Leading to a Physical Hydrogel”, A. Cappelli, S. Galeazzi, G. Giuliani, M. Anzini, M. Grassi, R. Lapasin, G. Grassi, R. Farra, B. Dapas, M. Aggravi, A. Donati, L. Zetta, A. Boccia, F. Bertini, S. Vomero. Macromolecules, 42, 2368-2378, 2009. 62) “New multidrug (dexamethasone and theophylline) PEG-conjugate: Synthesis, in vitro release studies and intestinal permeability”, M. Zacchigna, F. Cateni, D. Voinivich, M. Grassi, S. Drioli, G.M. Bonora. Journal of drug delivery science and technology, 19(3), 177-184, 2009. 63) “Investigation of PluronicVC F127–Water Solutions Phase Transitions by DSC and Dielectric Spectroscopy”, A. A. Barba, M. d’Amore, M. Grassi, S. Chirico, G. Lamberti, G. Titomanlio, Journal of applied polymer science, 114, 688 – 695, 2009. 64) “Scleroglucan/borax/drug hydrogels: structure characterisation by means of rheological and diffusion experiments”, M. Grassi, R. Lapasin, T. Coviello, P. Matricardi, C. Di Meo, F. Alhaique. Carbohydrate Polymers, 78, 377-383, 2009. 65) “Structural Characterization of Calcium Alginate Matrices by Means of Mechanical and Release Tests”, M. Grassi, C. Sandolo, D. Perin, T. Coviello, R. Lapasin, G. Grassi. Molecules, 14(8), 3003-3017, 2009. 66) “Role of E2F1–Cyclin E1-Cyclin E2 Circuit in Human Coronary Smooth Muscle Cell Proliferation and Therapeutic Potential of Its Downregulation by siRNAs”, B. Dapas, R. Farra, M. Grassi, C. Giansante, N. Fiotti, L. Uxa, G. Rainaldi, A. Mercatanti, A. Colombatti, P. Spessotto, V. Lacovich, G. Guarnieri, G. Grassi. Molecular Medicine 15(9-10), 297-306, 2009. 67) “Solid state mechanochemical activation of Silybum Marianum dry extract with betayclodextrins: characterization and bioavailability of the coground systems”, D. Voinovich, B. Perissutti, M.Grassi, N. Passerini, A. Bigotto. Journal of Pharmaceutical Sciences, 2009, 98(11), 4119-4129. 68) “Drug mechanochemical activation”, I. Colombo, G. Grassi, M. Grassi, Journal of Pharmaceutical Sciences, 2009, 98(11), 3961-3986. 69) “Solid lipid microparticles produced by spray congealing: influence of the atomizer on microparticle characteristics and mathematical modelling of drug release” N. Passerini, S. Qi , B. Albertini, M. Grassi, L. Rodriguez, Duncan Q.M. Craig. Journal of Pharmaceutical Sciences, 2010, 99(2), 916-931. 70) “PEG-Benzofulvene copolymer hydrogels for antibody delivery” M. Licciardi, M. Grassi, M. Di Stefano, L. Feruglio, G. Giuliani, S. Valenti, A. Cappelli, G. Giammona. International Journal of Pharmaceutics, 2010, 390, 183-190. 71) “Simultaneous Release and ADME processes of poorly water-soluble drugs: mathematical modelling”, Grassi G., Hasa D., Voinovich D., Perissutti B., Dapas B., Farra R., Franceschinis E., Grassi M. Molecular Pharmaceutics, 2010 7(5), 1488-1497. 72) “Current Strategies to Improve the Efficacy and the Delivery of Nucleic Acid Based Drugs”, Grassi M., Cavallaro G., Scirè S., Scaggiante B., Dapas B., Farra R., Baiz D., Giansante C., Guarnieri G., Perin D., Grassi G. Current Signal Transduction Therapy, 2010, 5(2), 92-120. 73) “Multidisciplinary approach on characterizing a mechanochemically activated composite of vinpocetine and crospovidone”, Hasa D., Voinovich D., Perissutti B., Bonifacio A., Grassi M., Franceschinis E., Dall'Acqua S., Speh M., Plavec J., Invernizzi S. Journal of Pharmaceutical Sciences, 2011, 100, 915-932. 74) “Improving siRNA Bio-Distribution and Minimizing Side Effects”, Scaggiante B., Dapas B., Farra R., Grassi M., Pozzato G., Giansante C., Fiotti N., Grassi G. Current Drug Metabolism, 2011, 12, 11-23. 75) “Mathematical modeling of simultaneous drug release and in vivo absorption”, Grassi M., Lamberti G., Cascone S., Grassi G. International Journal of Pharmaceutics, 2011, 418, 130-141. 76) “Mechanical spectroscopy and relaxometry on alginate hydrogels. A comparative analysis for structural characterization and network mesh size determination”, Turco G., Donati I., Grassi M., Marchioli G., Lapasin R., Paoletti S. Biomacromolecules, 2011, 12, 1272-1282. 77) “Enhanced Oral Bioavailability of Vinpocetine through Mechanochemical Salt Formation: Physico-Chemical Characterization and In Vivo Studies”, Hasa D., Voinovich D., Perissutti B., Grassi M., Bonifacio A., Sergo V., Cepek C., Chierotti M.R., Gobetto R., Dall’Acqua S., Invernizzi S. Pharmaceutical Research, 2011, 28(1), 1870-1880. 78) “Two-Dimensional Enzyme Diffusion Demonstrated in Laterally Confined DNA Monolayers”, Castronovo M., Lucesoli A., Parisse P., Kurnikova A., Malhotra A., Grassi M., Grassi G., Scaggiante B., Loredana Casalis L., Scoles G. Nature Communication, 2011, 2, 1-10, doi:10.1038/ncomms1296. 79) “Melt extruded helical waxy matrices as a new sustained drug delivery system”, Hasa D., Perissutti B., Grassi M., Zacchigna M, Pagotto M., Lenaz D., Kleinebudde P., Voinovich D. European Journal of Pharmaceutics and Biopharmaceutics 79 (2011) 592–600. 80) “Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells”, Farra R., Dapas B., Pozzato G., Scaggiante B., Agostini F., Zennaro C., Grassi M., Rosso N., Giansante C., Fiotti N., Grassi G. Digestive and Liver Disease 43 (2011) 1006– 1014. 81) “Theoretical and experimental analysis of drug release from an ensemble of polymeric particles containing amorphous and nano-crystalline drug”, N. Coceani, L. Magarotto, D. Ceschia, I. Colombo M. Grassi. Chemical Engineering Science, 71 (2012) 345-355. 82) “Hydration properties and proton exchange in aqueous sugar solutions studied by time domain nuclear magnetic resonance”, Aroulmoji V., Mathlouthi M., L. Feruglio L., Murano E., Grassi M. Food Chemistry, 2012, 132, 1644-1650 83) “Applications of supercritical fluids to enhance the dissolution behaviours of Furosemide by generation of microparticles and solid dispersions”, De Zordi N., Moneghini M., Kikic I., Grassi M., Castillo A.E.D.R., Solinas D., Bolger M. B., European Journal of Pharmaceutics and Biopharmaceutics, 2012, 81, 131-141. 84) “Mesh Size Distribution Determination of Interpenetrating Polymer Networks Hydrogels”, Pescosolido L., Feruglio L., Farra R., Fiorentino S., Colombo I., Coviello T., Matricardi P., Hennink W. E., Vermonden T., Grassi M. Soft Matter, 2012, 8, 7708-7715. 85) “Dissecting the expression of EEF1A1/A2 genes in human prostate cancer cells: the potential od EEF1A2 as a hallmark for prostate transformation and progression”, Scaggiante B., Dapas B., Bonin S., Grassi M., Zennaro C., Farra R., Cristiano L., Siracusano S., Zanconati F., Giansante C., Grassi G., British Journal of Cancer, 2012, 106, 166-173. 86) “Pharmaceutical applications of biocompatible polymer blends containing sodium alginate”, Dal Moro A., Barba A. A., Lamberti G., Grassi M., d’Amore M. Advances in Polymer Technology, 2012, 31, 219-230. 87) “Pharmacokinetic analysis of multi PEG-theophylline conjugates”, Grassi M., Bonora G.M., Drioli S., Cateni F., Zacchigna M. Computational Biology and Chemistry, 2012, 40, 7-14. 88) “Chemical Engineering and Drug Delivery”, Grassi M. Chemical and Biochemical Engineering Quarterly, 2012, 26(4), 307-308. 89) “Study on Polymer-Surfactant Interactions for the Improvement of Drug Delivery Systems Wettability”, De Simone I., Coceani N., Farra R., Fiorentino S. M., G. Grassi G., Lapasin R., Hasa D., Perissutti B., Grassi M., Voinovich D. Chemical and Biochemical Engineering Quarterly, 2012, 26(4), 405-415. 90) “Aptamers as nano-targeting delivery devices or anti-cancer drugs for fighting tumours”. B Scaggiante, B Dapas, R Farra, M Grassi, G Pozzato, C Giansante, N Fiotti, G Grassi. Current Drug Metabolism, 2013, 14, 565-582. 91) “Drug Salt Formation via Mechanochemistry: The Case Study of Vincamine”, Hasa D., Perissutti B., Cepek C., Bhardwaj S., Carlino E., Grassi M., Invernizzi S., Voinovich D. Molecular Pharmaceutics, 2013, 10 (1), 211–224. 92) “First-in-human trial of Dz13 for nodular basal-cell carcinoma” Grassi G., Grassi M. The Lancet, 2013, 381 (9880) pp 1797-1798. 93) “Mechanochemical activation of vincamine mediated by linear polymers: assessment of some “critical” steps” Hasa D., Perissutti B., Grassi M., Chierotti M. R., Gobetto R., Ferrario V., Lenazd D., Voinovich D. European Journal of Pharmaceutical Sciences, 2013, 50, 56-68. 94) “Reduction of melting temperature and enthalpy of drug crystals: theoretical aspects” Hasa D., Voinovich D., Perissutti B., Grassi G., Fiorentino S. M., Farra R., Abrami M., Colombo I., Grassi M. European Journal of Pharmaceutical Sciences, 2013, 50, 17-28. 95) “Guar gum/borax hydrogel: rheological, low field NMR and release characterizations” Coviello T., Matricardi P., Alhaique F., Farra R., Tesei G., Fiorentino S., Asaro F., Milcovich G., Grassi M. Express Polymer Letters, 2013 7(9), 733-746. 96) “Therapeutic potential of Nucleic acid-based drugs in coronary hyper-proliferative vascular diseases” Grassi G., Scaggiante B., Dapas B., Farra R., Tonon F., Lamberti G., Barba A., Fiorentino S., Fiotti N., Zanconati F., Abrami M., Grassi M. Current Medicinal Chemistry, 2013, 20(28), 3515-3538. 97) “Effects of Nanoscale Confinement on the Functionality of Nucleic Acids, and Applications in Nanomedicine” Castronovo M., Stopar A., Coral L., Redhu S. K., Vidonis M., Kumar V., Del Ben F., Grassi M., Nicholson A. W. Current Medicinal Chemistry, 2013, 20(28), 3539-3557. 98) “Improving drug efficacy and specificity by innovative drug delivery approaches”. Preface –Grassi G., Grassi M. Current Medicinal Chemistry, 2013, 20(28), 3427-3428. 99) “Physical characterization of Alginate-Pluronic F127 gel for endoluminal NABDs delivery” Abrami M., Dagostino I., Milcovich G., Fiorentino S., Farra R., Fioretta Asaro F., Lapasin R., Grassi G., Grassi M. Soft Matter, 2014, 10, 729-737. 100) “A 3D model for mechanistic control of drug release”, J. A. Ferreira, M. Grassi, E. Gudiño, P. de Oliveira. SIAM Journal on Applied Mathematics, 2014, 74(3), 620 - 633. 101) “Modeling of the reticulation kinetics

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