Gianfranco SINAGRA was born in Palermo in 12th June 1964, married, 3 children. Fellow of the European Society of Cardiology. Chief of Cardiovascular Department of Cardiology and Surgery at Azienda Ospedaliero-Universitaria, Ospedali Riuniti, Trieste. Professor of Cardiology for the Medicine and Biotechnologies Graduating Courses at the Trieste University. Supervisor or Lecturer in more than 300 National and International Congresses and to Formation Courses for hospital, extra-hospital and university Cardiologists. Component of the ANMCO Area –Heart Failure National Coordination, that provided for the compilation of the Heart Failure National Italian Guidelines. Component of the Group of Experts for the Superior Council of the Italian Health Ministry. Research fellow at the Department of Cardiologic Sciences of the St George’s Hospital of London (1989), and the Wallenberg Laboratory for Cardiovascular Research of the Sahlgrenska Hospital, Gothenburg University, Sweden (1991 and 1993). At the Cardiovascular Dept coordinates the Research Activity of the Myocardium Diseases’ Study Group and the clinical component of the Research Team in Molecular Cardiology of the International Centre for Genetic Engineering and Biotechnology, Research Area of Trieste. Project leader for several international studies in the setting of Heart Failure and Cardiomyopathies. He’s the author of more than 400 publications, 200 of them under Structured Work form, published in Books and National and International Scientific Magazines. More than 160 of the publications reviewed in Medline (h-index: 29) Impact Factor= 414.930.
Prof. GIANFRANCO SINAGRA Full Professor of Cardiology - MED 11 Head of Cardiovascular Department Azienda Ospedaliero-Universitaria “Ospedali Riuniti” of Trieste Director of Postgraduate School in Cardiovascular Disease - University of Trieste Graduated in Medicine (summa cum Laude) at the University of Palermo. Board of Cardiology (summa cum Laude) at the University of Trieste. Fellow of the European Society of Cardiology, member of the ESC-Working Group on Myocardial and Pericardial disease and of the ESC HF Association. Since 1999, Chief of the Cardiology Division at University Hospital of Cattinara, Trieste. Since 2009, Chief of Cardiovascular Department of Cardiology Azienda Ospedaliero-Universitaria “Ospedali Riuniti” Trieste. Since 2012 Deputy Director of the Medical, Surgical and Life Sciences Department of the University of Trieste. Since 2013, Delegate of the Rector of the University of Trieste for Scientific Research and technology. Since 2015, Member of the international committee for the guide and the integration of healthcare system between Italy and Slovenia Research fellow at the Department of Cardiologic Sciences of the St George’s Hospital of London (1989), and the Wallenberg Laboratory for Cardiovascular Research of the Sahlgrenska Hospital, Gothenburg University, Sweden (1991 and 1993). Professional Activities Direction of Human Resources, technologies and budget activities; Head of Cardiology ward and responsible for Medical activities; direction of clinical research activities within the Cardiovascular Department and liaison between clinical and basic research through the Direction of the CTC (Center for Translational Cardiology) of the AOUTS. The department is composed by 133 employees and generates over 2500 admission per year; 1400 Invasive procedures; more than 50.000 Outpatient clinics and non-invasive procedures. Certified autonomy in analysis of Endomyocardial Biopsy through histopathology, immunohistochemistry and molecular virology. Advertising, direction and promotion of trans border healthcare cooperation and in the development, update and implement of trans border protocols in the Emergency in cardiology (Project e-Cardionet, Italy-Slovenia 2007-2013 and further updates). Direction of monthly interdepartmental meetings of critical review of paradigmatic clinical scenarios and direction of semestral update meetings regarding scientific activities and international cooperation. Editorial and Scientific Activities Associate Editor of the European Journal of Heart Failure; Member of editorial board for Heart-BMJ, Nature and member of the International Scientific Board of the Journal of Cardiovascular Medicine and Macedonian Journal of Medical Sciences. Member of the del Scientific Committee of the Giornale Italiano di Cardiologia. Member of the End Point Clinical Event Committee of the ValHeFT Trial. Member of the Steering Committee of the BRING UP-ANMCO trial and of th Clinical Event end Point Committee of the studies SENIOR and GISSI HF (Ist. Farmacologico Mario Negri Milano). Chairman of the Cand-Heart Trial. Direction of the collaboration with IRCCS Burlo-Garofolo and with l’ICGEB. Since 2009 direction of the Center of Translational Cardiology (CTC) which collaborates with the University of Colorado, Denver, CO, USA, and the Mayo Clinic, Rochester, MN, USA. Direction of the research activities and collaboration to the following projects: - International registries, in particular ESC registries, such as EORP HF Pilot and Long Term, EORP AF General Pilot and Long term, EORP CMY Long Term, EORP PPCM and EORP Pregnancy and Heart Disease; - Multicentric clinical trials regarding Heart Failure Cardiomyopathies, Pulmonary Hypertension, Devices and Ischemic heart disease. Direction of the collaboration with the following institutions: - University of Colorado, Denver, Health Science Center, Division of Cardiology; L.Mestroni, MD, PhD; - Indiana University School of Medicine, Indianapolis. M.Vatta PhD; - Department of Cardiology, University of Cincinnati; Jeffrey Towbin PhD; - International Centre for Genetic Engineering and Biotechnology, Trieste; M.Giacca, MD, PhD; - Pathology Department, University of Trieste; R Bussani, MD; - IRCCS Burlo, Trieste; Department of Molecular Medicine; G. Severini PhD; - Virginia Commonwealth University, Medicine Department; A. Abate, MD, PhD e VCU Pauley Heart Center, Richmond, VA, USA; - Mario Negri Institute for Pharmacological Research, Milan, - Department of Cardiovascular research; R. Latini MD, PhD; - University of Trieste – Department of Architecture and Engineering – Science and Technology of Advanced Materials; Prof. Ing. O. Sbaizero Research Projects directed or as research unit: - Project “Identification of a Gene for Autosomal Dominant Dilated Cardiomyopathy on Chromosome 9”; National Institute of Health-USA, University of Colorado Cardiovascular Institute; - Project "FAMILIAL CARDIOMYOPATHY REGISTRY” (NIH 99-177) which attracted 1) NIH RO1HL69071, RR00051 GCRC-1575 e UCHSC, SOM AEF; 2) Giant Gene Titin (TTN) Involvement in Dilated Cardiomyopathy (Project NIH/NHLBI R95 – RS&G); 3) Analysis of Altered SCN5A Ion Channel Function in the Etiology of Dilated Cardiomyopathy (AHA 0615547Z); - Project American Heart Association SWA 12GRNT11770055 "Whole Exome Sequencing to Discover Dilated Cardiomyopathy Genes"; - Project Translational Research in Cardiology (CTC) funded by Fondazione Cassa di Risparmio di Trieste and Fondazione Generali; - Project of the Ministry of Health Finalized Research 2004: Molecular mechanisms of adverse or positive ventricular post-MI remodeling; - Project of the Ministry of Health Finalized Research: Italian Registry of Familial Dilated Cardiomyopathy (RICAF), clinical and genetic basis for the optimized treatment; - Project of the Ministry of Health Finalized Research 2008 ”Advanced Heart Failure: novel technologies in diagnosis and treatment”; - Project of the Ministry of Health Finalized Research: Dilated Cardiomyopathy and Gluten-dependent autoimmunity; - Project Piano Operativo Regionale (POR) of the European Fund for the regional development (FESR) 2007-13 ASSE 1 "innovation, research, technology and industrial sharing – sustainment of industrial research projects with high systemic impact to the development of research innovation and technologies network", Industrial research grant regarding molecular Biomedicine; Project E-cardionet, Territorial European Cooperation – Program for the trans border cooperation Italy-Slovenia, 2007-2013; Project NIH 1 R01 HL116906-01A1 “Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy”; Project FRA 1/2014-6/2016 (UniTS): “Novel strategies to improve outcomes in Myocardial Infarction: role of metabolic and nutritional factors”; Poject MIUR RF-2011-02348164 Biomedical finalized research “CARDIOriGEN - MicroRNAs inducing cardiac regeneration - From discovery towards clinical application CARDIOriGEN - MicroRNAs inducing cardiac regeneration”. International Awards - Leducq Award (2014, 5 years Project): Molecular Genetics, Pathogenesis and Protein-Replacement Therapy in Arrhythmogenic Cardiomyopathy. Author of more than 400 publications, 226 published, in extenso, indexed international journals. Total Impact factor (ISI Web of Knowledge, Journal of Citation Reports) 843,041; H-Index 39; Actual H-index 26; Total Citations 8288; Academic Activities Full professor of Cardiology at the University of Trieste for the following Courses: 1) Medicine and Surgery 2) Medical Biotechnologies 3) Professional Education 4) Nursing Graduating Inter-University Course of the University of Udine and Trieste 5) Postgraduate School in Cardiovascular Disease, Anesthesia, General Surgery and Emergency surgery, Medical Genetics, Geriatrics, Emergency Medicine, Internal Medicine, Nephrology, Neurology, Pediatrics and Medical Imaging. Supervisor for more than 100 graduation thesis and more than 80 fellowship commencements in Cardiology, Internal Medicine, Medical Genetics and Nursing. Referent for the ERASMUS Program and International Cardiovascular Fellowship. Scientific Director of the biannual course (since 1997) "Update in Cardiology – Heart Failure and Cardiomyopathies”. Member of the teaching body and of the working groups "Centro Regionale di Formazione per l'Area delle Cure Primarie" (CEFORMED) and of the Agenzia Regionale Sanità FVG. Invited speaker since 1990 to more than 500 national and international scientific meetings.