Sfogliando per Autore "'t Hoen, Pa"
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PubblicazioneDifferential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation( 2014)
;Morikawa, H ;Ohkura, N ;Vandenbon, A ;Itoh, M ;Nagao Sato, S ;Kawaji, H ;Lassmann, T ;Carninci, P ;Hayashizaki, Y ;Forrest, Ar ;Standley, Dm ;Date, H ;Sakaguchi, S ;FANTOM Consortium (Forrest, Ar ;Kawaji, H ;Rehli, M ;Baillie, Jk ;de Hoon, Mj ;Haberle, V ;Lassmann, T ;Kulakovskiy, Iv ;Lizio, M ;Itoh, M ;Andersson, R ;Mungall, Cj ;Meehan, Tf ;Schmeier, S ;Bertin, N ;Jørgensen, M ;Dimont, E ;Arner, E ;Schmidl, C ;Schaefer, U ;Medvedeva, Ya ;Plessy, C ;Vitezic, M ;Severin, J ;Semple, Ca ;Ishizu, Y ;Francescatto, M ;Alam, I ;Albanese, D ;Altschuler, Gm ;Archer, Ja ;Arner, P ;Babina, M ;Baker, S ;Balwierz, Pj ;Beckhouse, Ag ;Pradhan Bhatt, S ;Blake, Ja ;Blumenthal, A ;Bodega, B ;Bonetti, A ;Briggs, J ;Brombacher, F ;Burroughs, Am ;Califano, A ;Cannistraci, Cv ;Carbajo, D ;Chen, Y ;Chierici, M ;Ciani, Y ;Clevers, Hc ;Dalla, E ;Davis, Ca ;Deplancke, B ;Detmar, M ;Diehl, Ad ;Dohi, T ;Drabløs, F ;Edge, As ;Edinger, M ;Ekwall, K ;Endoh, M ;Enomoto, H ;Fagiolini, M ;Fairbairn, L ;Fang, H ;Farach Carson, Mc ;Faulkner, Gj ;Favorov, Av ;Fisher, Me ;Frith, Mc ;Fujita, R ;Fukuda, S ;Furlanello, C ;Furuno, M ;Furusawa, J ;Geijtenbeek, Tb ;Gibson, A ;Gingeras, T ;Goldowitz, D ;Gough, J ;Guhl, S ;Guler, R ;Gustincich, Stefano ;Ha, Tj ;Hamaguchi, M ;Hara, M ;Harbers, M ;Harshbarger, J ;Hasegawa, A ;Hasegawa, Y ;Hashimoto, T ;Herlyn, M ;Hitchens, Kj ;Ho Sui, Sj ;Hofmann, Om ;Hoof, I ;Hori, F ;Huminiecki, L ;Iida, K ;Ikawa, T ;Jankovic, Br ;Jia, H ;Joshi, A ;Jurman, G ;Kaczkowski, B ;Kai, C ;Kaida, K ;Kaiho, A ;Kajiyama, K ;Kanamori Katayama, M ;Kasianov, As ;Kasukawa, T ;Katayama, S ;Kato, S ;Kawaguchi, S ;Kawamoto, H ;Kawamura, Yi ;Kawashima, T ;Kempfle, Js ;Kenna, Tj ;Kere, J ;Khachigian, Lm ;Kitamura, T ;Klinken, Sp ;Knox, Aj ;Kojima, M ;Kojima, S ;Kondo, N ;Koseki, H ;Koyasu, S ;Krampitz, S ;Kubosaki, A ;Kwon, At ;Laros, Jf ;Lee, W ;Lennartsson, A ;Li, K ;Lilje, B ;Lipovich, L ;Mackay Sim, A ;Manabe, R ;Mar, Jc ;Marchand, B ;Mathelier, A ;Mejhert, N ;Meynert, A ;Mizuno, Y ;Morais, Da ;Morikawa, H ;Morimoto, M ;Moro, K ;Motakis, E ;Motohashi, H ;Mummery, Cl ;Murata, M ;Nagao Sato, S ;Nakachi, Y ;Nakahara, F ;Nakamura, T ;Nakamura, Y ;Nakazato, K ;van Nimwegen, E ;Ninomiya, N ;Nishiyori, H ;Noma, S ;Nozaki, T ;Ogishima, S ;Ohkura, N ;Ohmiya, H ;Ohno, H ;Ohshima, M ;Okada Hatakeyama, M ;Okazaki, Y ;Orlando, V ;Ovchinnikov, Da ;Pain, A ;Passier, R ;Patrikakis, M ;Persson, H ;Piazza, S ;Prendergast, Jg ;Rackham, Oj ;Ramilowski, Ja ;Rashid, M ;Ravasi, T ;Rizzu, P ;Roncador, M ;Roy, S ;Rye, Mb ;Saijyo, E ;Sajantila, A ;Saka, A ;Sakaguchi, S ;Sakai, M ;Sato, H ;Satoh, H ;Savvi, S ;Saxena, A ;Schneider, C ;Schultes, Ea ;Schulze Tanzil, Gg ;Schwegmann, A ;Sengstag, T ;Sheng, G ;Shimoji, H ;Shimoni, Y ;Shin, Jw ;Simon, C ;Sugiyama, D ;Sugiyama, T ;Suzuki, M ;Swoboda, Rk ;'t Hoen, Pa ;Tagami, M ;Takahashi, N ;Takai, J ;Tanaka, H ;Tatsukawa, H ;Tatum, Z ;Thompson, M ;Toyoda, H ;Toyoda, T ;Valen, E ;van de Wetering, M ;van den Berg, Lm ;Verardo, R ;Vijayan, D ;Vorontsov, Ie ;Wasserman, Ww ;Watanabe, S ;Wells, Ca ;Winteringham, Ln ;Wolvetang, E ;Wood, Ej ;Yamaguchi, Y ;Yamamoto, M ;Yoneda, M ;Yonekura, Y ;Yoshida, S ;Zabierowski, Se ;Zhang, Pg ;Zhao, X ;Zucchelli, S ;Summers, Km ;Suzuki, H ;Daub, Co ;Kawai, J ;Heutink, P ;Hide, W ;Freeman, Tc ;Lenhard, B ;Bajic, Vb ;Taylor, Ms ;Makeev, Vj ;Sandelin, A ;Hume, Da ;Carninci, PHayashizaki, Y.Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis, we assessed here how genome-wide patterns of DNA methylation or Foxp3 binding sites were associated with Treg-specific gene expression. We found that Treg-specific DNA hypomethylated regions were closely associated with Treg up-regulated transcriptional start site clusters, whereas Foxp3 binding regions had no significant correlation with either up- or down-regulated clusters in nonactivated Treg cells. However, in activated Treg cells, Foxp3 binding regions showed a strong correlation with down-regulated clusters. In accordance with these findings, the above two features of activation-dependent gene regulation in Treg cells tend to occur at different locations in the genome. The results collectively indicate that Treg-specific DNA hypomethylation is instrumental in gene up-regulation in steady state Treg cells, whereas Foxp3 down-regulates the expression of its target genes in activated Treg cells. Thus, the two events seem to play distinct but complementary roles in Treg-specific gene expression. WOS© Citazioni 85